Delanix 30

Delanix 30 Capsule

Generic: Dexlansoprazole 30 mg

Brand:

8.80 TK10 TK

Delanix 30
(Available)
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Categories:Medicine

Indications
Dexlansoprazole is indicated for-Healing of all grades of Erosive Esophagitis (EE) for up to 8 weeks.Maintain healing of Erosive Esophagitis and relief of heartburn for up to 6 month.Treatment of heartburn associated with symptomatic Non-Erosive Gastroesophageal Reflux Disease (GERD) for 4 weeks.
Drug Class
Proton Pump Inhibitor
Pharmacology
Dexlansoprazole delayed-release capsule is a Proton Pump Inhibitor (PPI), that inhibits gastric acid secretion. It is the R-enantiomer of lansoprazole (A racemic mixture of the R- and S-enantiomers). This is supplied as a Dual Delayed Release (DDR) formulation in a capsule for oral administration. Dexlansoprazole capsule contains a mixture of two types of enteric coated granules with different pH-dependent dissolution profiles.Dexlansoprazole is a PPI that suppresses gastric acid secretion by specific inhibition of the (H+/K+)-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Dexlansoprazole blocks the final step of acid production.
Dosage
Maintenance of Healed Erosive Esophagitis and relief of heartburn: 30 mg once daily.Symptomatic Non-Erosive GERD: 30 mg once daily for 4 weeks.Healing of Erosive Esophagitis: 60 mg once daily for up to 8 weeks.
Interaction
Lansoprazole appears to be a selective inhibitor of the cytochrome P-450 monooxygenase system; there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Lansoprazole on the oral combined contraceptive pill. Further assessment is currently underway. Physiological changes similar to those found with Omeprazole are likely to take place because of the reduction in gastric acid, which is likely to influence the bacterial colonization of the stomach and duodenum and also vitamin B12 absorption.
Contraindications
Dexlansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation.
Side Effects
Common side effects are Diarrhea, abdominal pain, nausea, upper respiratory tract Infection, vomiting & flatulence.
Precautions
Gastric malignancy, Clostridium difficile associated diarrhea, bone fracture, hypomagnesemia, concomitant use of Dexlansoprazole with Methotrexate.
Pediatric Use
Geriatrics: No dosage adjustment is necessary for elderly patients.Pediatrics: Safety and effectiveness of Dexlansoprazole in patients below 12 years age have not been established yet.Renal Impairment: No dosage adjustment is necessary for patients with renal impairment.Hepatic Impairment: No adjustment of Dexlansoprazole is necessary for patients with mild hepatic impairment. A maximum daily dose of 30 mg for patients with moderate hepatic impairment may be considered.
Overdose Effects
There have been no reports of significant overdose of Dexlansoprazole. Multiple doses of Dexlansoprazole 120 mg and a single dose of Dexlansoprazole 300 mg did not result in any severe adverse events.
Storage Condition
Store at temperature not exceeding 30ºC in a dry place. Protect from light & moisture.